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Biological Factors > Intercellular Signaling Peptides and Proteins > Angiogenic Proteins > Angiopoietin-like Proteins > Angiopoietin-Like Protein 4
... > Amino Acids, Peptides, and Proteins > Proteins > Intercellular Signaling Peptides and Proteins > Angiogenic Proteins > Angiopoietin-like Proteins > Angiopoietin-Like Protein 4
... > Amino Acids, Peptides, and Proteins > Peptides > Intercellular Signaling Peptides and Proteins > Angiogenic Proteins > Angiopoietin-like Proteins > Angiopoietin-Like Protein 4

Preferred term

Angiopoietin-Like Protein 4  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Angiopoietin related Protein 4
  • Angiopoietin-related Protein 4
  • ANGPTL4 Protein

Scope note

  • A secreted angiopoietin-like protein expressed under hypoxic conditions by ENDOTHELIAL CELLS. It inhibits cell proliferation, cell migration, and tubule formation; the inactive form accumulates in the endothelial EXTRACELLULAR MATRIX, reducing vascular leakage. ANGPTL4 has direct roles in regulating glucose and lipid metabolism, as well as INSULIN SENSITIVITY, and may also function as a regulator of angiogenesis and tumorigenesis.

History note

  • 2022(2018)

In other languages

URI

http://www.yso.fi/onto/mesh/D000075803

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