Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Fanconi Anemia Complementation Group N Protein
Amino Acids, Peptides, and Proteins > Proteins > Fanconi Anemia Complementation Group Proteins > Fanconi Anemia Complementation Group N Protein
Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Tumor Suppressor Proteins > Fanconi Anemia Complementation Group N Protein

Preferred term

Fanconi Anemia Complementation Group N Protein  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • FANCN Protein
  • PALB2 Protein
  • Partner and Localizer of BRCA2 Protein

Scope note

  • A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.

History note

  • 2018

In other languages

  • FANCN-proteiini

    Finnish

  • Fanconin anemiaan liittyvä komplementaatioryhmäproteiini N
  • Fanconin anemian komplementaatioryhmäproteiini N
  • komplementaatioryhmäproteiini N Fanconin anemiassa

URI

http://www.yso.fi/onto/mesh/D000076164

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 6/29/17