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Concept information

Preferred term

Sp7 Transcription Factor  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Osterix Protein

Scope note

  • An Sp transcription factor that contains three CYS2-HIS2 ZINC FINGERS. It binds to GC RICH SEQUENCES and performs an essential function in regulating gene expression for differentiation of OSTEOBLASTS. Mutations in the SP7 gene are associated with type 12 OSTEOGENESIS IMPERFECTA.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000076182

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