Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

Amino Acids, Peptides, and Proteins > Proteins > Tripartite Motif Proteins > Tripartite Motif-Containing Protein 28
Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Repressor Proteins > Tripartite Motif-Containing Protein 28
Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Repressor Proteins > Tripartite Motif-Containing Protein 28
... > Enzymes and Coenzymes > Enzymes > Ligases > Ubiquitin-Protein Ligase Complexes > Ubiquitin-Protein Ligases > Tripartite Motif-Containing Protein 28

Preferred term

Tripartite Motif-Containing Protein 28  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • TRIM28 Protein

Scope note

  • A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000076183

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 6/29/17