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... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Proto-Oncogene Proteins > c-Mer Tyrosine Kinase
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptor Protein-Tyrosine Kinases > c-Mer Tyrosine Kinase
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein-Tyrosine Kinases > Receptor Protein-Tyrosine Kinases > c-Mer Tyrosine Kinase
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein-Tyrosine Kinases > Receptor Protein-Tyrosine Kinases > c-Mer Tyrosine Kinase
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein-Tyrosine Kinases > Receptor Protein-Tyrosine Kinases > c-Mer Tyrosine Kinase

Preferred term

c-Mer Tyrosine Kinase  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • c Mer Proto Oncogene Tyrosine Kinase
  • c-Mer Proto-Oncogene Tyrosine Kinase
  • MERTK

Scope note

  • A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000076202

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