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Macromolecular Substances > Multiprotein Complexes > Mechanistic Target of Rapamycin Complex 1
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > TOR Serine-Threonine Kinases > Mechanistic Target of Rapamycin Complex 1
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > TOR Serine-Threonine Kinases > Mechanistic Target of Rapamycin Complex 1
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein Serine-Threonine Kinases > TOR Serine-Threonine Kinases > Mechanistic Target of Rapamycin Complex 1

Preferred term

Mechanistic Target of Rapamycin Complex 1  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • Complex, mTORC1
  • mTORC1
  • mTORC1 Complex
  • Target of Rapamycin Complex 1
  • TORC1
  • TOR Complex 1

Scope note

  • An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.

History note

  • 2018 (2013)

In other languages

URI

http://www.yso.fi/onto/mesh/D000076222

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