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Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > MRE11 Homologue Protein
Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Poly-ADP-Ribose Binding Proteins > MRE11 Homologue Protein
Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Poly-ADP-Ribose Binding Proteins > MRE11 Homologue Protein
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Endonucleases > Endodeoxyribonucleases > MRE11 Homologue Protein
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Deoxyribonucleases > Endodeoxyribonucleases > MRE11 Homologue Protein
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Deoxyribonucleases > Exodeoxyribonucleases > MRE11 Homologue Protein
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Exonucleases > Exodeoxyribonucleases > MRE11 Homologue Protein

Preferred term

MRE11 Homologue Protein  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Meiotic Recombination 11 Homolog 1 Protein
  • MRE11A Protein

Scope note

  • A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000076228

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