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Concept information

Preferred term

Heat Shock Transcription Factors  

Type

  • Topical Descriptor

Entry terms

  • Heat Shock Transcription Factor

Scope note

  • Heat and cold stress-inducible, transcription factors that bind to inverted 5'-NGAAN-3' pentamer DNA sequences and are regulated by POLY-ADP-RIBOSYLATION. They play essential roles as transcriptional activators of the HEAT-SHOCK RESPONSE by inducing expression of large classes of MOLECULAR CHAPERONES and heat-shock proteins. They also function in DNA REPAIR; transcriptional reactivation of latent HIV-1; and pre-mRNA processing and nuclear export of HSP70 HEAT-SHOCK PROTEINS during heat stress.

History note

  • 2018 (1992)

In other languages

URI

http://www.yso.fi/onto/mesh/D000076249

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