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Amino Acids, Peptides, and Proteins > Proteins > Bacterial Proteins > CRISPR-Associated Protein 9
Amino Acids, Peptides, and Proteins > Proteins > CRISPR-Associated Proteins > CRISPR-Associated Protein 9
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Endonucleases > Endodeoxyribonucleases > CRISPR-Associated Protein 9
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Deoxyribonucleases > Endodeoxyribonucleases > CRISPR-Associated Protein 9

Preferred term

CRISPR-Associated Protein 9  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Cas9 Endonuclease
  • Cas9 Enzyme
  • Cas9 Protein
  • Endonuclease, Cas9
  • Enzyme, Cas9

Scope note

  • An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9.

History note

  • 2019

In other languages

URI

http://www.yso.fi/onto/mesh/D000076987

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