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Inorganic Chemicals > Coordination Complexes > Oxaliplatin
Organic Chemicals > Coordination Complexes > Oxaliplatin

Preferred term

Oxaliplatin  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • 1,2 Diaminocyclohexane Platinum Oxalate
  • 1,2-Diaminocyclohexane Platinum Oxalate
  • 1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II)
  • L-OHP Cpd
  • Oxalato-(1,2-cyclohexanediamine)platinum II
  • Oxaliplatine
  • Oxaliplatin, (SP-4-2-(1R-trans))-isomer
  • Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1)
  • Platinum(II)-1,2-cyclohexanediamine Oxalate

Scope note

  • An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.

History note

  • 2019 (1981)

In other languages

URI

http://www.yso.fi/onto/mesh/D000077150

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