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... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptor Protein-Tyrosine Kinases > Anaplastic Lymphoma Kinase
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein-Tyrosine Kinases > Receptor Protein-Tyrosine Kinases > Anaplastic Lymphoma Kinase
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein-Tyrosine Kinases > Receptor Protein-Tyrosine Kinases > Anaplastic Lymphoma Kinase
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein-Tyrosine Kinases > Receptor Protein-Tyrosine Kinases > Anaplastic Lymphoma Kinase

Preferred term

Anaplastic Lymphoma Kinase  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • ALK Kinase
  • ALK Tyrosine Kinase Receptor
  • Anaplastic Lymphoma Receptor Tyrosine Kinase
  • CD246 Antigen
  • NPM-ALK
  • Nucleophosmin Anaplastic Lymphoma Kinase
  • Nucleophosmin-Anaplastic Lymphoma Kinase

Scope note

  • A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.

History note

  • 2019 (1994)

In other languages

URI

http://www.yso.fi/onto/mesh/D000077548

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