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Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Dioxoles > Trabectedin
... > Heterocyclic Compounds > Heterocyclic Compounds, Fused-Ring > Heterocyclic Compounds, 2-Ring > Isoquinolines > Tetrahydroisoquinolines > Trabectedin

Preferred term

Trabectedin  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Ecteinascidin 743
  • NSC 684766
  • Yondelis

Scope note

  • A complex structure that includes isoquinolines joined by a cyclic ester; it is a DNA-binding agent and guanine N2 alkylator derived from the marine tunicate, Ecteinascidia turbinata. Trabectedin is used for the treatment of advanced soft-tissue SARCOMA, after failure of ANTHRACYCLINES or IFOSFAMIDE drug therapy.

History note

  • 2019 (1996)

In other languages

URI

http://www.yso.fi/onto/mesh/D000077606

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