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Cell Physiological Phenomena > Cell Death > Regulated Cell Death > Necroptosis

Preferred term

Necroptosis  

Type

  • Topical Descriptor

Broader concept

Note

  • do not confuse with NECROSIS the pathological process

Scope note

  • A form of regulated cell death initiated by perturbations of extracellular or intracellular homeostasis that trigger a specific cell death pathway involving the activation of RIPK3 and MLKL (mixed lineage kinase domain like pseudokinase). Morphological changes include cytoplasmic and organellar swelling, rupture of the PLASMA MEMBRANE, and CHROMATIN CONDENSATION.

History note

  • 2020

In other languages

URI

http://www.yso.fi/onto/mesh/D000079302

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