Concept information
Preferred term
Synucleinopathies
Type
-
Topical Descriptor
Broader concept
Narrower concepts
Entry terms
- alpha Synucleinopathies
- alpha-Synucleinopathies
- alpha-Synucleinopathy
- alpha Synuclein Pathologies
- alpha Synuclein Pathology
- a-Synucleinopathies
- a-Synucleinopathy
Scope note
- Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent examples of synucleinopathy.
History note
- 2020
In other languages
-
Finnish
-
hermokudoksen rappeumataudit ominaispiirteenään alfasynukleiinikertyminen
-
monijärjestelmäsurkastuma
-
synukleinopatia
-
Swedish
-
Alfa-synukleinopatier
URI
http://www.yso.fi/onto/mesh/D000080874
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