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Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxidoreductases Acting on CH-NH Group Donors > mu-Crystallins
Amino Acids, Peptides, and Proteins > Proteins > Eye Proteins > Crystallins > mu-Crystallins

Preferred term

mu-Crystallins  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • CRYM Protein
  • Crystallin mu
  • Ketimine Reductase mu Crystallin
  • Ketimine Reductase mu-Crystallin
  • mu, Crystallin
  • mu-Crystallin, Ketimine Reductase
  • NADP Regulated Thyroid Hormone Binding Protein
  • NADP-Regulated Thyroid Hormone Binding Protein
  • Protein, CRYM
  • Protein, THBP
  • Reductase mu-Crystallin, Ketimine
  • THBP Protein

Scope note

  • A subclass of crystallins expressed highly in lens of diurnal Australian MARSUPIALS and in neural tissue, muscle, and kidney in humans. It is not a structural protein accounting for the transparency of the human lens unlike other crystallins but instead plays a role in thyroid hormone bioavailability. It is also a cerebral ketimine reductase which reduces cyclic imines (e.g., DELTA(1)-PIPERIDINE-2-CARBOXYLIC ACID; CYSTATHIONINE KETIMINE and LANTHIONINE KETIMINE) in mammalian brain. Mutations in mu-crystallins are associated with an autosomal dominant NONSYNDROMIC DEAFNESS.

History note

  • 2022(1992)

In other languages

URI

http://www.yso.fi/onto/mesh/D000090803

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