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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Serine Proteases > Tripeptidyl-Peptidase 1
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Exopeptidases > Dipeptidyl-Peptidases and Tripeptidyl-Peptidases > Tripeptidyl-Peptidase 1
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Exopeptidases > Aminopeptidases > Tripeptidyl-Peptidase 1

Preferred term

Tripeptidyl-Peptidase 1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • CLN2 Protein
  • Peptidase I, Tripeptidyl
  • Protein, CLN2
  • Protein, TPP1
  • TPP1 Protein
  • Tripeptidyl Aminopeptidase I
  • Tripeptidyl Peptidase I
  • Tripeptidyl-Peptidase I
  • Tripeptidyl Protease I

Scope note

  • Lysosomal Serine proteases that release N-terminal tripeptide from a polypeptide and cleave peptides between hydrophobic residues. An enzyme that in humans encoded by the TPP1 gene. It is involved in the degradation of bone collagen. Mutations in this gene are associated with the CEROID LIPOFUSCINOSIS, NEURONAL, 2; and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE CEROID LIPOFUSCINOSIS, NEURONAL, 2; AND SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 7.

History note

  • 2022 (1993)

In other languages

URI

http://www.yso.fi/onto/mesh/D000091346

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