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... > Chemical Actions and Uses > Specialty Uses of Chemicals > Laboratory Chemicals > Indicators and Reagents > Cross-Linking Reagents > Proteolysis Targeting Chimera

Preferred term

Proteolysis Targeting Chimera  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Chimeras, Proteolysis Targeting
  • PROTAC Proteolysis Targeting Chimera
  • PROTACs
  • Proteolysis Targeting Chimeras
  • Targeting Chimeras, Proteolysis

Scope note

  • Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME.

History note

  • 2023

In other languages

  • proteolyysin aiheuttavat yhdistelmämolekyylit

    Finnish

  • proteiinien hajoamisen aiheuttavat kimeeriset molekyylit
  • proteiinien hajoamisen aiheuttavat yhdistelmämolekyylit
  • proteolyysin aiheuttava yhdistelmämolekyyli
  • proteolyysin aiheuttavat kimeeriset molekyylit
  • proteolyysin indusoivat yhdistelmämolekyylit

URI

http://www.yso.fi/onto/mesh/D000094243

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