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... > Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > RNA > RNA, Untranslated > RNA, Small Untranslated > RNA, Guide, CRISPR-Cas Systems

Preferred term

RNA, Guide, CRISPR-Cas Systems  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Guide RNA (CRISPR-Cas Systems)
  • Guide RNA, CRISPR Cas Systems
  • Guide RNA, CRISPR-Cas Systems
  • RNA, Guide (CRISPR-Cas Systems)

Note

  • do not confuse with RNA, GUIDE, KINETOPLASTIDA; do not confuse sgRNA (SINGLE-GUIDE RNA) with sgRNA (SUBGENOMIC RNA)

Scope note

  • A component of CRISPR-Cas SYSTEMS. Cas endodeoxyribonucleases assemble with a guide RNA complex, a hybrid of CRISPR RNA (crRNA) and transactivating crRNA (tracrRNA) molecules, to form an active complex that cleaves DNA. crRNA and tracrRNA can be synthetically fused into a single RNA molecule, namely single guide RNA. Synthetic sgRNA is used with CRISPR-Cas SYSTEMS for targeted GENE EDITING.

History note

  • 2023

In other languages

URI

http://www.yso.fi/onto/mesh/D000094704

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