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Polycyclic Compounds > Macrocyclic Compounds > Polyketides > Polyether Polyketides
Organic Chemicals > Lactones > Polyketides > Polyether Polyketides
Organic Chemicals > Ethers > Ethers, Cyclic > Polyether Polyketides
Polycyclic Compounds > Macrocyclic Compounds > Ethers, Cyclic > Polyether Polyketides

Preferred term

Polyether Polyketides  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • Marine Ladder Polyethers
  • Polyether Antibiotics

Scope note

  • Polycyclic polyketides with distinctive ladder shaped multiple polyether motifs. In STREPTOMYCES polycyclic polyketide backbones are assembled by type I modular polyketide synthases which then are modified by epoxidase and epoxide hydrolase to achieve their stereochemistry. Polyether ionophore antibiotics coordinate alkali metal cations with their multiple oxygen atoms which disturbs sodium/potassium concentration gradient. They are widely used to treat and control COCCIDIOSIS. Structurally related MARINE LADDER POLYETHERS are neurotoxins.

History note

  • 2024

In other languages

URI

http://www.yso.fi/onto/mesh/D000095662

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