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Amino Acids, Peptides, and Proteins > Proteins > Nerve Tissue Proteins > Neurexins
... > Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > Cell Adhesion Molecules > Cell Adhesion Molecules, Neuronal > Neurexins
... > Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > Cell Adhesion Molecules > Cell Adhesion Molecules, Neuronal > Neurexins
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > Cell Adhesion Molecules > Cell Adhesion Molecules, Neuronal > Neurexins
... > Biological Factors > Antigens > Antigens, Surface > Cell Adhesion Molecules > Cell Adhesion Molecules, Neuronal > Neurexins

Preferred term

Neurexins  

Type

  • Topical Descriptor

Broader concept

Scope note

  • Presynaptic cell-adhesion molecules that bind postsynaptic NEUROLIGINS to form calcium-dependent trans-synaptic adhesions. Neurexins recruit synaptic scaffolding proteins via their PDZ DOMAINS. Distribution and interaction with neuroligins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neurexins are associated with cognitive diseases such AUTISM SPECTRUM DISORDER; SCHIZOPHRENIA and Pitt-Hopkins-like syndrome 2.

History note

  • 2024

In other languages

URI

http://www.yso.fi/onto/mesh/D000096784

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RDF/XML TURTLE JSON-LD Created 7/26/23, last modified 4/5/23