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Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > AIRE Protein

Preferred term

AIRE Protein  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • APECED Protein
  • Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein
  • Autoimmune Regulator Protein
  • Protein, APECED
  • Protein, Autoimmune Regulator
  • Regulator Protein, Autoimmune

Scope note

  • A transcriptional regulator primarily expressed in medullary thymic epithelial cells. It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY.

History note

  • 2024 (1997)

In other languages

URI

http://www.yso.fi/onto/mesh/D000096927

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