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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Acid Anhydride Hydrolases > Pyrophosphatases > Nudix Hydrolases

Preferred term

Nudix Hydrolases  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • Hydrolase, Nudix
  • Nucleoside Diphosphates Linked to Moiety X Hydrolases
  • Nucleoside Diphosphates-Linked to Moiety-X Hydrolases
  • Nudix Hydrolase
  • Nudix Proteins

Scope note

  • A group of Mg2+/Mn2+-dependent mainly pyrophosphohydrolases that hydrolyzes structures of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates (e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15) are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental intellectual disorder.

History note

  • 2024

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URI

http://www.yso.fi/onto/mesh/D000096964

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