Concept information
Preferred term
Degrons
Type
-
Topical Descriptor
Broader concept
Entry terms
- Box Motif, Destruction
- Box Motifs, Destruction
- C-Degron
- C Degrons
- C-Degrons
- Destruction Box Motif
- Destruction Box Motifs
- Motif, Destruction Box
- Motif, PEST
- Motifs, Destruction Box
- Motifs, PEST
- N-Degron
- N Degrons
- N-Degrons
- PEST Motif
- PEST Motifs
Scope note
- Minimal elements within a protein that are sufficient for recognition and degradation by a proteolytic apparatus. Inherent degrons are comprised of short linear amino acid sequences and secondary protein structural features that increase the affinity to E3 LIGASE; and are involved in regulating the specificity and timing of PROTEIN DEGRADATION. Acquired degrons are mostly transient and conferred by post-translational modifications of specific amino acids within proteins. (From Mol Cell. 2016 Sep 15;63(6):1055-65)
History note
- 2024
In other languages
-
Finnish
-
itsetuhosekvenssi
-
itsetuhosekvenssit
-
proteiinin hajottamiseen osallistuva osa proteiinissa
URI
http://www.yso.fi/onto/mesh/D000097791
{{label}}
{{#each values }} {{! loop through ConceptPropertyValue objects }}
{{#if prefLabel }}
{{/if}}
{{/each}}
{{#if notation }}{{ notation }} {{/if}}{{ prefLabel }}
{{#ifDifferentLabelLang lang }} ({{ lang }}){{/ifDifferentLabelLang}}
{{#if vocabName }}
{{ vocabName }}
{{/if}}