Concept information
Preferred term
Amiloride
Type
-
Topical Descriptor
Broader concept
Entry terms
- Amidal
- Amiduret Trom
- Amiloberag
- Amiloride Hydrochloride
- Amiloride Hydrochloride, Anhydrous
- Anhydrous Amiloride Hydrochloride
- Hydrochloride, Amiloride
- Hydrochloride, Anhydrous Amiloride
- Kaluril
- Midamor
- Midoride
- Trom, Amiduret
Scope note
- A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
History note
- 86(72); was see under PYRAZINES 1975-85, was Prov 1972-74
URI
http://www.yso.fi/onto/mesh/D000584
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