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Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > Histocompatibility Antigens Class II
Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > Histocompatibility Antigens Class II
Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > Histocompatibility Antigens Class II
Biological Factors > Antigens > Isoantigens > Histocompatibility Antigens > Histocompatibility Antigens Class II
Biological Factors > Antigens > Antigens, Surface > Histocompatibility Antigens > Histocompatibility Antigens Class II

Preferred term

Histocompatibility Antigens Class II  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Related concepts

Entry terms

  • Antigen, Class II
  • Antigen, I-A
  • Antigen, IA
  • Antigen, Ia-Like
  • Antigens, Class II
  • Antigens, Ia
  • Antigens, Ia-Like
  • Antigens, Immune Response
  • Antigens, Immune-Response-Associated
  • Class II Antigen
  • Class II Antigens
  • Class II Histocompatibility Antigen
  • Class II Histocompatibility Antigens
  • Class II Major Histocompatibility Antigen
  • Class II Major Histocompatibility Antigens
  • Class II Major Histocompatibility Molecules
  • Class II MHC Proteins
  • I A Antigen
  • I-A Antigen
  • I-A-Antigen
  • IA Antigen
  • Ia Antigens
  • Ia Like Antigen
  • Ia-Like Antigen
  • Ia Like Antigens
  • Ia-Like Antigens
  • II Peptide, MHC
  • Immune Response Antigens
  • Immune Response Associated Antigens
  • Immune-Response-Associated Antigens
  • MHC Class II Molecule
  • MHC Class II Molecules
  • MHC II Molecules
  • MHC-II Molecules
  • MHC II Peptide
  • MHC II Peptides
  • Molecules, MHC-II
  • Peptide, MHC II
  • Peptides, MHC II

Note

  • human & animal; see also HLA ANTIGENS & specifics for human

Scope note

  • Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.

History note

  • 1989 (1973); use ANTIGENS, IMMUNE RESPONSE 1981-88

In other languages

URI

http://www.yso.fi/onto/mesh/D000949

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