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Carbohydrates > Glycoconjugates > Glycoproteins > Asialoglycoproteins
Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Asialoglycoproteins

Preferred term

Asialoglycoproteins  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Asialoglycoprotein
  • Desialylated Glycoproteins
  • Glycoproteins, Desialylated

Scope note

  • Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.

History note

  • 85

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URI

http://www.yso.fi/onto/mesh/D001212

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