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Concept information

Preferred term

beta 2-Microglobulin  

Type

  • Topical Descriptor

Entry terms

  • Thymotaxin

Scope note

  • An 11-kDa protein associated with the outer membrane of many cells including LYMPHOCYTES. It is the small subunit of MHC CLASS I MOLECULES. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, CEREBROSPINAL FLUID, and urine of healthy individuals, and to a much greater degree in the urine and plasma of patients with tubular PROTEINURIA, renal failure, or kidney transplants.

History note

  • 1991 (1975); use BETA 2 MICROGLOBULIN 1984-1990

In other languages

URI

http://www.yso.fi/onto/mesh/D001613

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