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Biological Factors > Toxins, Biological > Bacterial Toxins > Botulinum Toxins
Amino Acids, Peptides, and Proteins > Proteins > Bacterial Proteins > Botulinum Toxins
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Metalloendopeptidases > Botulinum Toxins
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Metalloproteases > Metalloendopeptidases > Botulinum Toxins

Preferred term

Botulinum Toxins  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Related concepts

Entry terms

  • Botulin
  • Botulinum Neurotoxin
  • Botulinum Neurotoxins
  • Botulinum Toxin
  • Clostridium botulinum Toxins
  • Neurotoxin, Botulinum
  • Neurotoxins, Botulinum
  • Toxin, Botulinum
  • Toxins, Clostridium botulinum

Note

  • /antag permitted but consider also BOTULINUM ANTITOXIN

Scope note

  • Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.

History note

  • 78; was BOTULINUM TOXIN 1969-77 (Prov 1969-71)

In other languages

  • botuliinit

    Finnish

  • botuliini
  • botulinum
  • botulinumtoksiini
  • botulinumtoksiinit
  • botulinustoksiini
  • botulinustoksiinit
  • Botulinumtoxiner

    Swedish

  • Botulinumgifter
  • Clostridium botulinum toxiner

URI

http://www.yso.fi/onto/mesh/D001905

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