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Amino Acids, Peptides, and Proteins > Proteins > Protein Precursors > Proinsulin > C-Peptide
... > Chemical Actions and Uses > Pharmacologic Actions > Physiological Effects of Drugs > Hormones, Hormone Substitutes, and Hormone Antagonists > Hormones > Peptide Hormones > Pancreatic Hormones > Insulins > Proinsulin > C-Peptide
... > Amino Acids, Peptides, and Proteins > Peptides > Peptide Hormones > Pancreatic Hormones > Insulins > Proinsulin > C-Peptide

Preferred term

C-Peptide  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Connecting Peptide
  • C Peptide, Proinsulin
  • C-Peptide, Proinsulin
  • Proinsulin C Peptide
  • Proinsulin C-Peptide

Note

  • from proinsulin only: not for peptide fragments from other proteins ( = PEPTIDE FRAGMENTS)

Scope note

  • The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.

History note

  • 84(77); was see under PEPTIDES 1977-83

In other languages

URI

http://www.yso.fi/onto/mesh/D002096

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