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Biological Factors > Toxins, Biological > Bacterial Toxins > Cholera Toxin
... > Enzymes and Coenzymes > Enzymes > Transferases > Glycosyltransferases > Pentosyltransferases > ADP Ribose Transferases > Cholera Toxin
Biological Factors > Toxins, Biological > Enterotoxins > Cholera Toxin

Preferred term

Cholera Toxin  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Cholera Enterotoxin CT
  • Cholera Exotoxin
  • Choleragen
  • Enterotoxin CT, Cholera
  • Exotoxin, Cholera

Note

  • /antag permitted but consider also ANTITOXINS

Scope note

  • An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.

History note

  • 78

In other languages

URI

http://www.yso.fi/onto/mesh/D002772

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