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... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Mixed Function Oxygenases > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > Cholesterol Side-Chain Cleavage Enzyme
Enzymes and Coenzymes > Cytochromes > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > Cholesterol Side-Chain Cleavage Enzyme
... > Amino Acids, Peptides, and Proteins > Proteins > Hemeproteins > Cytochromes > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > Cholesterol Side-Chain Cleavage Enzyme
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Mixed Function Oxygenases > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 11 > Cholesterol Side-Chain Cleavage Enzyme
Enzymes and Coenzymes > Cytochromes > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 11 > Cholesterol Side-Chain Cleavage Enzyme
... > Amino Acids, Peptides, and Proteins > Proteins > Hemeproteins > Cytochromes > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 11 > Cholesterol Side-Chain Cleavage Enzyme

Preferred term

Cholesterol Side-Chain Cleavage Enzyme  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • 20,22 Desmolase
  • 20,22-Desmolase
  • Cholesterol Desmolase
  • Cholesterol Monooxygenase (Side-Chain-Cleaving)
  • CYP 11A1
  • CYP11A1
  • Cytochrome P450 11A1
  • Cytochrome P 450 CYP11A1
  • Cytochrome P-450 CYP11A1
  • Cytochrome P-450(scc)
  • Cytochrome P450scc

Scope note

  • A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.

History note

  • 2003 (1975)

In other languages

URI

http://www.yso.fi/onto/mesh/D002786

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