Concept information
Preferred term
Cisplatin
Type
-
Topical Descriptor
Broader concept
Entry terms
- cis Diamminedichloroplatinum
- cis-Diamminedichloroplatinum
- cis-Diamminedichloroplatinum(II)
- cis-Dichlorodiammineplatinum(II)
- cis Platinum
- cis-Platinum
- Diamminodichloride, Platinum
- Dichlorodiammineplatinum
- Platinum Diamminodichloride
Scope note
- An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
History note
- 84(81); was see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1981-83; was PLATINUM DIAMMINODICHLORIDE see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1974-80; DIAMMONIUM CHLOROPLATINUM COMPOUNDS was heading 1974-83
In other languages
-
Finnish
-
Cisplatin Ebewe
-
Cisplatin Hospira
-
Cisplatin Pfizer
-
cisplatinum
-
kisplatiini
-
Swedish
-
Platinol
URI
http://www.yso.fi/onto/mesh/D002945
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