Concept information
Preferred term
Clozapine
Type
-
Topical Descriptor
Broader concept
Entry terms
- Clozaril
- Leponex
Scope note
- A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
History note
- 91(75); was see under DIBENZAZEPINES 1975-90
In other languages
-
Finnish
-
Clozapin Hexal
-
Clozapine Actavis
-
Clozapine Sandoz
-
Froidir
-
Leponex
-
Swedish
-
Leponex
URI
http://www.yso.fi/onto/mesh/D003024
{{label}}
{{#each values }} {{! loop through ConceptPropertyValue objects }}
{{#if prefLabel }}
{{/if}}
{{/each}}
{{#if notation }}{{ notation }} {{/if}}{{ prefLabel }}
{{#ifDifferentLabelLang lang }} ({{ lang }}){{/ifDifferentLabelLang}}
{{#if vocabName }}
{{ vocabName }}
{{/if}}