Concept information
Preferred term
Complement Pathway, Alternative
Type
-
Topical Descriptor
Broader concept
Entry terms
- Alternative Complement Activation Pathway
- Alternative Complement Pathway
- Complement Activation Pathway, Alternative
- Properdin Pathway
Scope note
- Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
History note
- 91(79); was see under COMPLEMENT ACTIVATION 1979-90
In other languages
-
Finnish
-
komplementtijärjestelmän oikotieaktivaatio
-
properdiiniaktivaatiotie
-
vaihtoehtoinen komplementtiaktivaatio
-
vaihtoehtoinen komplementtijärjestelmän aktivaatio
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Swedish
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Alternativ komplementaktivering
-
Komplementaktiveringsbanor, alternativa
URI
http://www.yso.fi/onto/mesh/D003170
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