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... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement C1

Preferred term

Complement C1  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • C1 Complement
  • Complement 1
  • Complement, C1
  • Complement Component 1
  • Component 1, Complement

Note

  • /antag permitted but consider also COMPLEMENT C1 INACTIVATOR PROTEINS

Scope note

  • The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.

History note

  • 2006 (1975)

In other languages

URI

http://www.yso.fi/onto/mesh/D003172

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