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... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement C1 > Complement C1s
Enzymes and Coenzymes > Enzymes > Hydrolases > Complement Activating Enzymes > Complement C1s
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement Activating Enzymes > Complement C1s

Preferred term

Complement C1s  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • C 1 Esterase
  • C1 Esterase
  • C1s Complement
  • Complement 1 Esterase
  • Complement 1s
  • Complement, C1s
  • Complement Component 1s
  • Component 1s, Complement
  • Esterase, C 1
  • Esterase, C1
  • Esterase, Complement 1

Scope note

  • A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).

History note

  • 2006 (1978)

In other languages

URI

http://www.yso.fi/onto/mesh/D003173

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