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... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Serum Globulins > Immunoglobulins > Antibodies > Autoantibodies > Complement C3 Nephritic Factor
... > Amino Acids, Peptides, and Proteins > Proteins > Globulins > Serum Globulins > Immunoglobulins > Antibodies > Autoantibodies > Complement C3 Nephritic Factor
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Immunoglobulins > Antibodies > Autoantibodies > Complement C3 Nephritic Factor
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement Inactivator Proteins > Complement C3 Nephritic Factor

Preferred term

Complement C3 Nephritic Factor  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Autoantibody, C3NeF IgG
  • C3 NeF
  • C3 NeF IgG Autoantibodies
  • C3NeF IgG Autoantibodies
  • C3 NeF IgG Autoantibody
  • C3NeF IgG Autoantibody
  • C 3 Nephritic Factor
  • C3 Nephritic Factor
  • Complement 3 Nephritic Factor
  • IgG Autoantibody, C3NeF

Scope note

  • An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.

History note

  • 2006 (1978)

In other languages

URI

http://www.yso.fi/onto/mesh/D003178

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