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... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Mixed Function Oxygenases > Cytochrome P-450 Enzyme System
Enzymes and Coenzymes > Cytochromes > Cytochrome P-450 Enzyme System
Amino Acids, Peptides, and Proteins > Proteins > Hemeproteins > Cytochromes > Cytochrome P-450 Enzyme System

Preferred term

Cytochrome P-450 Enzyme System  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • CYP450 Family
  • CYP450 Superfamily
  • Cytochrome P 450
  • Cytochrome P-450
  • Cytochrome P450
  • Cytochrome P 450 Enzyme
  • Cytochrome P-450 Enzyme
  • Cytochrome P 450 Enzymes
  • Cytochrome P-450 Enzymes
  • Cytochrome P 450 Families
  • Cytochrome P-450 Families
  • Cytochrome p450 Families
  • Cytochrome P 450 Superfamily
  • Cytochrome P-450 Superfamily
  • Cytochrome P450 Superfamily
  • Enzyme, Cytochrome P-450
  • Enzyme, P-450
  • Enzyme, P450
  • Enzymes, Cytochrome P-450
  • Enzymes, P-450
  • Enzymes, P450
  • P 450 Enzyme
  • P-450 Enzyme
  • P450 Enzyme
  • P-450 Enzyme, Cytochrome
  • P 450 Enzymes
  • P-450 Enzymes
  • P450 Enzymes
  • P-450 Enzymes, Cytochrome
  • Superfamily, CYP450
  • Superfamily, Cytochrome P-450
  • Superfamily, Cytochrome P450

Note

  • general or unspecified; prefer specific cytochrome P-450's

Scope note

  • A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.

History note

  • 73; CYTOCHROME P-450 OXYGENASE was NM 1977-96

In other languages

URI

http://www.yso.fi/onto/mesh/D003577

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