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Amino Acids, Peptides, and Proteins > Peptides > Peptides, Cyclic > Dactinomycin
Polycyclic Compounds > Macrocyclic Compounds > Peptides, Cyclic > Dactinomycin
Heterocyclic Compounds > Heterocyclic Compounds, Fused-Ring > Heterocyclic Compounds, 3-Ring > Dactinomycin

Preferred term

Dactinomycin  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Actinomycin D
  • Meractinomycin

Scope note

  • A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

History note

  • 66; ACTINOMYCIN was heading 1963-95

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URI

http://www.yso.fi/onto/mesh/D003609

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