Concept information
Preferred term
Debrisoquin
Type
-
Topical Descriptor
Broader concept
Entry terms
- Debrisoquine
Scope note
- An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
History note
- 91(73); was see under ISOQUINOLINES 1973-90
In other languages
-
Finnish
-
Swedish
URI
http://www.yso.fi/onto/mesh/D003647
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