Concept information
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Central Nervous System Diseases
Brain Diseases
Leukoencephalopathies
Demyelinating Autoimmune Diseases, CNS
Immune System Diseases
Autoimmune Diseases
Autoimmune Diseases of the Nervous System
Demyelinating Autoimmune Diseases, CNS
Nervous System Diseases
Autoimmune Diseases of the Nervous System
Demyelinating Autoimmune Diseases, CNS
...
Models, Theoretical
Models, Biological
Disease Models, Animal
Nervous System Autoimmune Disease, Experimental
Investigative Techniques
Models, Animal
Disease Models, Animal
Nervous System Autoimmune Disease, Experimental
Preferred term
Encephalomyelitis, Autoimmune, Experimental
Type
-
Topical Descriptor
Broader concept
Entry terms
- Allergic Encephalomyelitis, Experimental
- Autoimmune Encephalomyelitis, Experimental
- Autoimmune Experimental Encephalomyelitis
- Encephalomyelitis, Autoimmune Experimental
- Encephalomyelitis, Experimental Allergic
- Encephalomyelitis, Experimental Autoimmune
- Experimental Allergic Encephalomyelitides
- Experimental Allergic Encephalomyelitis
- Experimental Autoimmune Encephalomyelitis
- Experimental Encephalomyelitis, Autoimmune
Note
- coordinate with specific demyelinating disease if pertinent
Scope note
- An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
History note
- 2005 (1964)
In other languages
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Finnish
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allerginen aivo-selkäydintulehdus
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allerginen aivojen ja selkäytimen tulehdus
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allerginen enkefalomyeliitti
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allerginen myelenkefaliitti
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kokeellinen autoimmuuni aivo-selkäydintulehdus
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kokeellinen autoimmuuni aivojen ja selkäytimen tulehdus
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kokeellinen autoimmuuni myelenkefaliitti
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Swedish
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Autoimmun experimentell encefalomyelit
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Encefalomyelit, allergisk
URI
http://www.yso.fi/onto/mesh/D004681
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