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... > Organic Chemicals > Hydrocarbons > Hydrocarbons, Cyclic > Hydrocarbons, Aromatic > Polycyclic Aromatic Hydrocarbons > Naphthalenes > Tetrahydronaphthalenes > Podophyllotoxin > Etoposide
... > Polycyclic Compounds > Polycyclic Aromatic Hydrocarbons > Naphthalenes > Tetrahydronaphthalenes > Podophyllotoxin > Etoposide
... > Organic Chemicals > Hydrocarbons > Hydrocarbons, Cyclic > Hydrocarbons, Aromatic > Benzene Derivatives > Benzyl Compounds > Lignans > Podophyllotoxin > Etoposide
Carbohydrates > Glycosides > Glucosides > Etoposide

Preferred term

Etoposide  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Demethyl Epipodophyllotoxin Ethylidine Glucoside
  • Eposide

Scope note

  • A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

History note

  • 87(81); was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80

In other languages

  • etoposidi

    Finnish

  • Eposin
  • Etopofos
  • Etoposide Pfizer
  • etoposidum
  • Vepesid
  • Etoposid

    Swedish

  • Eposin
  • Vepesid

URI

http://www.yso.fi/onto/mesh/D005047

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