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Chemical Actions and Uses > Pharmacologic Actions > Molecular Mechanisms of Pharmacological Action > Enzyme Inhibitors > Folic Acid Antagonists

Preferred term

Folic Acid Antagonists  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Acid Antagonist, Folic
  • Antagonist, Folic Acid
  • Antifolate
  • Antifolates
  • Dihydrofolate Reductase Inhibitor
  • Dihydrofolate Reductase Inhibitors
  • Folic Acid Antagonist
  • Inhibitor, Dihydrofolate Reductase
  • Inhibitors, Dihydrofolate Reductase
  • Reductase Inhibitor, Dihydrofolate
  • Reductase Inhibitors, Dihydrofolate

Scope note

  • Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)

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URI

http://www.yso.fi/onto/mesh/D005493

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