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... > Enzymes and Coenzymes > Enzymes > Isomerases > Intramolecular Oxidoreductases > Aldose-Ketose Isomerases > Glucose-6-Phosphate Isomerase

Preferred term

Glucose-6-Phosphate Isomerase  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Glucosephosphate Isomerase
  • Isomerase, Glucose 6 Phosphate
  • Isomerase, Glucosephosphate
  • Isomerase, Phosphoglucose
  • Isomerase, Phosphohexose
  • Phosphoglucose Isomerase
  • Phosphohexose Isomerase

Scope note

  • An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.

History note

  • 1998(1965)

In other languages

URI

http://www.yso.fi/onto/mesh/D005956

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