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Hemic and Lymphatic Diseases > Lymphatic Diseases > Lymphoproliferative Disorders > Heavy Chain Disease
Immune System Diseases > Immunoproliferative Disorders > Lymphoproliferative Disorders > Heavy Chain Disease
Hemic and Lymphatic Diseases > Hematologic Diseases > Blood Protein Disorders > Paraproteinemias > Heavy Chain Disease
Immune System Diseases > Immunoproliferative Disorders > Paraproteinemias > Heavy Chain Disease

Preferred term

Heavy Chain Disease  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Related concepts

Entry terms

  • gamma Chain Disease
  • gamma-Chain Disease
  • gamma-Chain Diseases
  • mu Chain Disease
  • mu-Chain Disease
  • mu-Chain Diseases

Note

  • specify the immunoglobulin fragment coord NIM, as gamma chain dis = HEAVY CHAIN DISEASE (IM) + IMMUNOGLOBULIN GAMMA-CHAINS (NIM); ALPHA-CHAIN DISEASE see IMMUNOPROLIFERATIVE SMALL INTESTINAL DISEASE is available

Scope note

  • A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.

History note

  • 66(64)

In other languages

  • raskasketjutauti

    Finnish

  • Franklin
  • Franklinin tauti
  • Franklins sjukdom
  • gamma heavy chain disease
  • gammaraskasketjutauti
  • morbus cum catenis gravibus gamma
  • morbus Franklin
  • Tungkedjesjukdom

    Swedish

URI

http://www.yso.fi/onto/mesh/D006362

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