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Amino Acids, Peptides, and Proteins > Proteins > Serpins > Antithrombin Proteins > Hirudins
Amino Acids, Peptides, and Proteins > Peptides > Serpins > Antithrombin Proteins > Hirudins
... > Chemical Actions and Uses > Pharmacologic Actions > Molecular Mechanisms of Pharmacological Action > Enzyme Inhibitors > Protease Inhibitors > Serine Proteinase Inhibitors > Serpins > Antithrombin Proteins > Hirudins

Preferred term

Hirudins  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Hirudin

Scope note

  • Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.

History note

  • 2005(1963)

In other languages

URI

http://www.yso.fi/onto/mesh/D006629

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