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Nutritional and Metabolic Diseases > Metabolic Diseases > Metabolism, Inborn Errors > Metal Metabolism, Inborn Errors > Hypophosphatasia
Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Genetic Diseases, Inborn > Metabolism, Inborn Errors > Metal Metabolism, Inborn Errors > Hypophosphatasia

Preferred term

Hypophosphatasia  

Type

  • Topical Descriptor

Broader concept

Related concepts

Note

  • defic of blood phosphatases; do not use /congen & do not coord with INFANT, NEWBORN, DISEASES

Scope note

  • A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)

History note

  • 72(66)

In other languages

URI

http://www.yso.fi/onto/mesh/D007014

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