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... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Alcohol Oxidoreductases > NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases > Isocitrate Dehydrogenase

Preferred term

Isocitrate Dehydrogenase  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Dehydrogenase, NAD Isocitrate
  • Isocitrate Dehydrogenase (NAD+)
  • Isocitrate Dehydrogenase, NAD
  • NAD Isocitrate Dehydrogenase

Scope note

  • An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.

History note

  • 65(63)

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URI

http://www.yso.fi/onto/mesh/D007521

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