Concept information
Preferred term
Ivermectin
Type
-
Topical Descriptor
Broader concept
Entry terms
- Eqvalan
- Ivomec
- Mectizan
- MK 933
- MK-933
- MK933
- Stromectol
Scope note
- A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
History note
- 1987; for MECTIZAN use IVERMECTIN (NM) 1987-1999
In other languages
-
Finnish
-
Swedish
URI
http://www.yso.fi/onto/mesh/D007559
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