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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Exopeptidases > Dipeptidyl-Peptidases and Tripeptidyl-Peptidases > Peptidyl-Dipeptidase A

Preferred term

Peptidyl-Dipeptidase A  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • ACE1 Angiotensin Converting Enzyme 1
  • ACE1 Angiotensin-Converting Enzyme 1
  • ACE1 Protein
  • Angiotensin Converting Enzyme
  • Angiotensin Converting Enzyme 1
  • Angiotensin I Converting Enzyme
  • Angiotensin I-Converting Enzyme
  • Antigens, CD143
  • Carboxycathepsin
  • Carboxypeptidase I, Dipeptidyl
  • CD143 Antigens
  • Dipeptidyl Carboxypeptidase I
  • Dipeptidyl Peptidase A
  • Kininase A
  • Kininase II
  • Peptidase P

Scope note

  • A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020).

History note

  • 1994; for TONIN use KININASE II 1984-93

In other languages

URI

http://www.yso.fi/onto/mesh/D007703

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